The Forest 1 whole-Brain Computer Interface (wBCI) is a wearable neural interface that supports both imaging (1,2) and neuromodulation over large volumes of the human brain intraoperatively, or in patients with a craniotomy or sonolucent cranioplasty. Interfacing with the whole-human brain is what distinguishes Forest’s technology; the wBCI provides the potential to understand, diagnose and treat many indications in parallel at the level of full circuits and systems.